Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Isl1  ISL1 transcription factor, LIM/homeodomain   (Synonyms: Islet 1)
Results	Reference
1	J:207610 Akiyama R, Kawakami H, Taketo MM, Evans SM, Wada N, Petryk A, Kawakami Y, Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the beta-catenin pathway. Dev Biol. 2014 Mar 1;387(1):37-48
1*	J:173839 Bertrand N, Roux M, Ryckebusch L, Niederreither K, Dolle P, Moon A, Capecchi M, Zaffran S, Hox genes define distinct progenitor sub-domains within the second heart field. Dev Biol. 2011 May 15;353(2):266-74
1	J:184511 Cohen ED, Miller MF, Wang Z, Moon RT, Morrisey EE, Wnt5a and Wnt11 are essential for second heart field progenitor development. Development. 2012 Jun;139(11):1931-40
1	J:283391 de Soysa TY, Ranade SS, Okawa S, Ravichandran S, Huang Y, Salunga HT, Schricker A, Del Sol A, Gifford CA, Srivastava D, Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects. Nature. 2019 Aug;572(7767):120-124
1*	J:46975 Ericson J, Norlin S, Jessell TM, Edlund T, Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development. 1998 Mar;125(6):1005-15
1	J:316286 Francou A, Saint-Michel E, Mesbah K, Kelly RG, TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field. Development. 2014 Nov;141(22):4320-31
1	J:238678 Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis AK, Sawa Y, Sasaki H, Ozono K, Suzuki K, Yashiro K, GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep. 2016 Jul 26;16(4):1026-38
1	J:245319 Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Liu F, Liu Y, Poleshko A, Padmanabhan A, Raum JC, Li L, Morrisey EE, Lu MM, Won KJ, Epstein JA, HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science. 2015 Jun 26;348(6242):aaa6071
1*	J:267824 Jia G, Preussner J, Chen X, Guenther S, Yuan X, Yekelchyk M, Kuenne C, Looso M, Zhou Y, Teichmann S, Braun T, Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement. Nat Commun. 2018 Nov 19;9(1):4877
1	J:127596 Klaus A, Saga Y, Taketo MM, Tzahor E, Birchmeier W, Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18531-6
1	J:330214 Lania G, Franzese M, Adachi N, Bilio M, Flore G, Russo A, D'Agostino E, Angelini C, Kelly RG, Baldini A, A phenotypic rescue approach identifies lineage regionalization defects in a mouse model of DiGeorge syndrome. Dis Model Mech. 2022 Sep 1;15(9):dmm049415
1	J:180125 Lee S, Lee JW, Lee SK, UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program. Dev Cell. 2012 Jan 17;22(1):25-37
1	J:239071 Li X, Yue X, Pastor WA, Lin L, Georges R, Chavez L, Evans SM, Rao A, Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8267-E8276
1	J:306706 Metais A, Lamsoul I, Melet A, Uttenweiler-Joseph S, Poincloux R, Stefanovic S, Valiere A, Gonzalez de Peredo A, Stella A, Burlet-Schiltz O, Zaffran S, Lutz PG, Moog-Lutz C, Asb2alpha-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development. Circ Res. 2018 Mar 16;122(6):e34-e48
1*	J:207639 Nelson DO, Jin DX, Downs KM, Kamp TJ, Lyons GE, Irx4 identifies a chamber-specific cell population that contributes to ventricular myocardium development. Dev Dyn. 2014 Mar;243(3):381-92
1	J:143444 Park EJ, Watanabe Y, Smyth G, Miyagawa-Tomita S, Meyers E, Klingensmith J, Camenisch T, Buckingham M, Moon AM, An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development. 2008 Nov;135(21):3599-610
1	J:185712 Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, HarveyRP, An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007 Mar 9;128(5):947-59
1	J:94587 Radde-Gallwitz K, Pan L, Gan L, Lin X, Segil N, Chen P, Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. J Comp Neurol. 2004 Sep 27;477(4):412-21
1	J:213214 Shenje LT, Andersen P, Uosaki H, Fernandez L, Rainer PP, Cho GS, Lee DI, Zhong W, Harvey RP, Kass DA, Kwon C, Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors. Elife. 2014;3:e02164
1	J:213584 Vincent SD, Mayeuf-Louchart A, Watanabe Y, Brzezinski JA 4th, Miyagawa-Tomita S, Kelly RG, Buckingham M, Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum Mol Genet. 2014 Oct 1;23(19):5087-101
1	J:244345 Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T, Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest. 2017 Jun 01;127(6):2235-2248
1	J:143443 Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, Schwartz RJ, Martin JF, Wang F, Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development. 2008 Nov;135(21):3611-22
1	J:199412 Zhang T, Liu J, Zhang J, Thekkethottiyil EB, Macatee TL, Ismat FA, Wang F, Stoller JZ, Jun is required in Isl1-expressing progenitor cells for cardiovascular development. PLoS One. 2013;8(2):e57032